Drug Distribution by Dr. Bharat Jain on Scribd
Monday, April 29, 2019
Thursday, December 20, 2018
Biopharmaceutics and Pharmacokinetics Question Bank
02
Marks
1. Utility
curve and therapeutic window and Accumulation index.
2.
What
is the influence of drug pka and GI pH on drug absorption ?
3.
Give significance of binding of drug.
4.
Write S. N. on First pass effect.
5.
Plasma concentration time curve.
6.
Biopharmaceutical classification system.
7.
Discuss
briefly factors affecting gastric emptying of drug.
8.
What
are the possible mechanisms of enzyme induction and enzyme inhibition?
9.
Explain
the objectives of bioavailability studies.
10. Give
significance of tissue binding of drug.
11. Explain in short
Blood Brain Barrier.
12. What are the
various sites of drug metabolism in the body ?
13. Name the methods
used to calculate KE from urinary excretion data. What are the advantages of
urinary data over plasma data ?
14. Explain what dose-dependent
kinetics is. Give methods of detection.
15. Define and
explain in short- MRT (Mean Residence Time).
16. Define and
explain in short- AUC.
17. Explain in short
: elimination rate constant.
18. Explain in short
: Cmax and tmax.
19. Give possible
reasons of non linearity in pharmacokinetics.
20. Define the term
Volume of Distribution, Apparent Volume of Distribution.
- Explain in
brief disposition process.
- Define the
term Bioequivalence, Chemical Equivalence, Therapeutic Equivalence and
Clinical Equivalence.
- Define the term
Phagocytosis & Pinocytosis
05
marks
1.
pH-partition
theory. Discuss the assumptions, limitations and significance of pH- partition
hypothesis.
2.
Handerson-Hasslebach
Equation
3.
Drug
protein binding.
4.
Factors
affecting renal clearance
5.
Enterohepatic
Circulation
6.
Clinical
applications of clearance.
7.
Plasma
concentration and therapeutic response.
8.
How
the organ size and perfusion rate influence the drug distribution?
9.
Explain
the different physiological barriers to the drug distribution.
10. What is the
influence of various disease states on plasma protein level and drug binding ?
11. What is
flip-flop phenomenon ?
12. Discuss the
types of physiological models.
13. Permeability
limited drug distribution
14. Volume of
distribution and its importance.
15. Regulatory
requirements in BA/BE studies.
16. Presystemic
metabolism.
17. Two
compartmental model.
18. Wagnor- Nelson method.
19. Individualization
of dosage regimen.
20. Give the significance of Therapeutic Drug
Monitoring
21. Give BCS
classification of Drugs
22. Write S. N. on
dissolution models
23. Write S. N. on
theories of dissolution
24. Explain Phase I
and Phase II reactions
25. Factors
Influences renal excretions
26. IVIVC
- Write Short
note on methods of enhancement
of bioavailability
28. Michaelis
Menten equation
29. Estimation
of Km and Vmax
30. Pulmonary
and Mammary Minor pathways of drug excretions
10
Marks
1.
Discuss
formulation and dosage form related factors affecting oral bioavailability.
2.
Discuss
perfusion and permeability limitations of drug distribution. Support your
answer with suitable examples.
3.
Discuss
in detail the different mechanisms of drug transport.
4.
Discuss
the methods of estimation of bioavailability parameters.
5.
Explain
one compartment model of a drug and mathematical treatment upon IV bolus
dosing.
6.
Explain
the factors affecting dosage regimens.
7.
Discuss
the physicochemical factors affecting drug absorption. Highlight diffusion
layer model/film theory.
8.
Explain various pharmaceutical factors affecting drug
absorption.
9.
Explain
the factors influencing renal excretion of drug.
10. What are
pharmacokinetic models ? What is the importance and utility of developing such
models ? Discuss briefly the types of pharmacokinetic models.
11. Describe
in detail factors influencing protein binding of drug.
12. What
is biotransformation? Explain the process of biotransformation and give factors
affecting biotransformation.
13. Describe
in detail study parameters used for Bioavailability / Bioequivalence studies.
14.
Explain one compartmental open model for IV bolus drug
administration. Add a note on Non-compartmental analysis of drug.
15.
What are pharmacokinetic models? Give the types and significance
of pharmacokinetic models.
16.
Describe
various pharmacokinetic parameters and study designs used in BA/BE studies.
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